Intracellular cAMP signaling by soluble adenylyl cyclase.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21490586.
- Also identified by DOI 10.1038/ki.2011.95 and PMC identifier 3105178.
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Abstract
Soluble adenylyl cyclase (sAC) is a recently identified source of the ubiquitous second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is distinct from the more widely studied source of cAMP, the transmembrane adenylyl cyclases (tmACs); its activity is uniquely regulated by bicarbonate anions, and it is distributed throughout the cytoplasm and in cellular organelles. Due to its unique localization and regulation, sAC has various functions in a variety of physiological systems that are distinct from tmACs. In this review, we detail the known functions of sAC, and we reassess commonly held views of cAMP signaling inside cells.
Medical subject headings
- Adenylyl Cyclases
- Cyclic AMP
- Cytoplasm
- Organelles
- Second Messenger Systems