The biology of immunoglobulin free light chains and kidney injury.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21490587.
- Also identified by DOI 10.1038/ki.2011.94.
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Abstract
Kidney injury caused by immunoglobulin free light chains (FLCs) in the setting of plasma cell dyscrasias is common and associated with increased morbidity and mortality. All compartments of the kidney may be affected, from the glomerulus to the tubulointerstitium, in a wide variety of disease patterns. Here, we review our current knowledge of the biological effects of FLCs and the mechanisms that lead to kidney injury.
Medical subject headings
- Immunoglobulin Light Chains
- Kidney
- Kidney Diseases
- Paraproteinemias
- Plasma Cells