FEN nucleases: bind, bend, fray, cut.
editorial · Level V
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- Record sourced from PubMed, PMID 21496637.
- Also identified by DOI 10.1016/j.cell.2011.03.039 and PMC identifier 3515068.
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Abstract
In this issue, Orans et al. (2011) and Tsutakawa et al. (2011) report exciting insights into the molecular principles governing diverse endo- and exonucleolytic cleavage specificities of members of the RAD2/FEN superfamily of nucleases, which have critical roles in DNA replication and maintenance.