Does metabolite deficiency mark oncogenic cell cycles?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21529708.
- Also identified by DOI 10.1016/j.cell.2011.04.003.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Genome instability occurs early in the development of most cancers. Bester et al. now provide evidence that oncogenic signals trigger cell division without coordinate nucleotide synthesis, engendering aberrant DNA replication and damage that could promote carcinogenesis. A mismatch between proliferation and metabolite production may characterize oncogenic cell cycles.