Protease power strokes force proteins to unfold.
basic_science · Level V
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- Record sourced from PubMed, PMID 21529709.
- Also identified by DOI 10.1016/j.cell.2011.04.007 and PMC identifier 4676939.
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Abstract
ATP-dependent proteases degrade proteins in the cytosol of cells. Two recent articles, by Aubin-Tam et al. (2011) and Maillard et al. (2011 [this issue]), use single-molecule optical tweezers to show directly that these molecular machines use the energy derived from ATP hydrolysis to mechanically unfold and translocate its substrates into the proteolytic chamber.