Rearrangement of the beta T-cell receptor gene in a monocytoid B-cell lymphoma.
case_report · Level V
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- Record sourced from PubMed, PMID 2153018.
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Abstract
We describe an unusual case of monocytoid lymphoma displaying a rearrangement of the T-cell receptor beta-chain gene associated with a rearrangement of the immunoglobulin heavy-chain gene, and of the lambda light-chain gene. This lymphoma was morphologically similar to previous cases in the literature, and was clinically of low grade. The lymphoma expressed the lambda light chain, HLA-DR, CD21, and CD22. Though the B-cell lineage of this lymphoma seems very likely, the genotypic profile raises a cautionary note regarding the supposed high stage of differentiation of monocytoid lymphomas.
Medical subject headings
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Lymphoma