Opposing effects of nasal epithelial NAD(P)H dehydrogenase quinine 1 and heme oxygenase 1 expression on upper and lower airway symptoms in adolescents with asthma.
Level V
Where this comes from
- Record sourced from PubMed, PMID 21531452.
- Also identified by DOI 10.1016/j.jaci.2011.03.029 and PMC identifier 3169320.
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Abstract
NQO1 and HO-1 expression in nasal epithelium are inversely correlated indicating that non-NRF2 mechanisms may play an important role in regulation of these genes. Further, NQO1 and HO-1 expression have opposing relationships with upper and lower airways symptoms, suggesting that induction of phase II enzymes could result in pleiotropic clinical effects.
Medical subject headings
- Asthma
- Gene Expression Regulation
- Heme Oxygenase-1
- NAD(P)H Dehydrogenase (Quinone)
- NF-E2-Related Factor 2
- Nasal Mucosa