Shedding LIGHT on severe asthma.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21546971.
- Also identified by DOI 10.1038/nm0511-547 and PMC identifier 3170000.
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Abstract
Moderate to severe asthma is difficult to treat because recurring bouts of inflammation in the lungs induce fibrosis, which reduces lung elasticity, gas exchange and responses to conventional therapy. A recent study identifies the tumor necrosis factor family member LIGHT as an essential mediator of airway fibrosis in a mouse model of chronic asthma (pages 596–603).
Medical subject headings
- Asthma
- Tumor Necrosis Factor Ligand Superfamily Member 14