Of cancer and cave fish.
Level V
Where this comes from
- Record sourced from PubMed, PMID 21548400.
- Also identified by DOI 10.1038/nrc3036 and PMC identifier 3971416.
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Abstract
We propose that the drivers of carcinogenesis lie more in the adaptive changes that are enabled by local or systemic alterations of tissue architecture than in the genetic changes observed in cancer cells. A full understanding of cancer biology and therapy through a cataloguing of the cancer genome is unlikely unless it is integrated into an evolutionary and ecological context.
Medical subject headings
- Biological Evolution
- Cell Transformation, Neoplastic
- Ecology
- Fishes
- Neoplasms