Deadly teamwork: neural cancer stem cells and the tumor microenvironment.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21549324.
- Also identified by DOI 10.1016/j.stem.2011.04.013 and PMC identifier 3494093.
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Abstract
Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic networks and the niche microenvironment. The CSC-microenvironment relationship is complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy.
Medical subject headings
- Cell Communication
- Glioblastoma
- Neoplastic Stem Cells
- Nervous System Neoplasms
- Stem Cell Niche