Lymphomatoid granulomatosis in the acquired immunodeficiency syndrome. Evidence of Epstein-Barr virus infection and B-cell clonal selection without myc rearrangement.
case_report · Level V
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Abstract
A case of lymphomatoid granulomatosis of lung that occurred in a patient with the acquired immunodeficiency syndrome (AIDS) was studied by light microscope, electron microscope, cell surface markers, and Southern blot test. Clonal selection of two clones of B-cells was seen. Two clones were infected with Epstein-Barr virus. There was no c-myc rearrangement. Lymphomatoid granulomatosis in patients with AIDS may represent multiclonal selection of B-lymphocytes in association with Epstein-Barr virus infection.
Medical subject headings
- Acquired Immunodeficiency Syndrome
- DNA, Viral
- Gene Rearrangement
- Herpesvirus 4, Human
- Lung Neoplasms
- Lymphomatoid Granulomatosis
- Oncogenes