Combining quantitative proteomics data processing workflows for greater sensitivity.
basic_science · Level V
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- Record sourced from PubMed, PMID 21552256.
- Also identified by DOI 10.1038/nmeth.1604.
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Abstract
We here describe a normalization method to combine quantitative proteomics data. By merging the output of two popular quantification software packages, we obtained a 20% increase (on average) in the number of quantified human proteins without suffering from a loss of quality. Our integrative workflow is freely available through our user-friendly, open-source Rover software (http://compomics-rover.googlecode.com/).
Medical subject headings
- Electronic Data Processing
- Proteomics
- Software