Evidence that the endothelin A receptor can enhance IgE-dependent anaphylaxis in mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21555149.
- Also identified by DOI 10.1016/j.jaci.2011.04.012 and PMC identifier 3565840.
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Abstract
Endothelin-1 has been implicated in inflammatory disorders including allergic responses. Here, we present evidence in mice that endothelin-1 may act via ET<sub>A</sub> to increase mast cell degranulation and thus exacerbate clinical features of anaphylaxis.
Medical subject headings
- Anaphylaxis
- Immunoglobulin E
- Passive Cutaneous Anaphylaxis
- Receptor, Endothelin A