Estrogen receptor transrepresses brain inflammation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21565607.
- Also identified by DOI 10.1016/j.cell.2011.04.018.
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Abstract
Estrogen receptors (ERs) have long been implicated in the etiology of multiple sclerosis, but no clear molecular mechanisms have linked ERs to the disease's pathology. Now Saijo et al. (2011) provide evidence that ERβ activates a transrepression pathway that suppresses inflammation and inhibits progression of pathology in a mouse model of multiple sclerosis.