Metabolic homeostasis: HDACs take center stage.
editorial · Level V
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- Record sourced from PubMed, PMID 21565608.
- Also identified by DOI 10.1016/j.cell.2011.04.017 and PMC identifier 3860372.
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Abstract
Hormonal regulation of glucose and lipid metabolism is pivotal for metabolic homeostasis and energy balance. Two studies in this issue of Cell (Mihaylova et al., 2011 and Wang et al., 2011) introduce a new conserved signaling mechanism controlling catabolic gene expression: class IIa histone deacetylases (HDACs) regulate Foxo activity in Drosophila and mice.