A hormone sends instant messages to the genome.

Prokesch, Andreas; Lazar, Mitchell A · Cell · 2011

basic_science · Level V

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Abstract

Bridging a gap between transcriptomics and the study of cis-acting elements (cistromics), Hah et al. (2011) apply a next-generation sequencing technique to gain an unprecedented view of the changes in RNA synthesis that occur following estrogen receptor activation in human breast cancer cells.