Hexokinase: a novel sugar kinase coupled to renal epithelial cell survival.
editorial · Level V
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- Record sourced from PubMed, PMID 21566638.
- Also identified by DOI 10.1038/ki.2011.20.
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Abstract
Hexokinases have emerged as novel mediators of the antiapoptotic effects of growth factors in a wide variety of cells. These effects have been attributed to highly regulated direct physical and functional interactions with mitochondria. The demonstration that mitochondrial hexokinases can prevent apoptogenic 'Bax attack' in proximal tubule cells suggests a need to reexamine the specific contributions of hexokinases and glucose metabolism in this nephron segment and elsewhere within the kidney.
Medical subject headings
- Epithelial Cells
- Hexokinase
- Kidney Diseases
- Kidney Tubules, Proximal
- Mitochondrial Membranes
- Reperfusion Injury