Involvement of solitary tract nucleus in control of nociceptive transmission in cat spinal cord neurons.

Abstract

In cats anesthetized with Nembutal and immobilized with Flaxedil, extracellular recordings were made from dorsal horn neurons and lamina X neurons in the lumbar spinal cord. The nociceptive responses of these neurons elicited by peripheral nerve stimulation were significantly inhibited by stimulation of the nucleus tractus solitarius (NTS) at low intensity without any noticeable cardiovascular reaction. As usual, the late response or C-response was found to be preferentially inhibited by NTS stimulation as compared with the early response or A-response. The effective current intensity for NTS stimulation-produced inhibition ranged from 80 microA to 200 microA. Stronger inhibition was induced when the stimulating site was within or in the immediate vicinity of the NTS. There was no significant difference in the efficacy of the NTS stimulation-produced inhibition of nociceptive response between dorsal horn neurons and lamina X neurons. A similar inhibitory effect was elicited by microinjection of monosodium glutamate into the NTS area. The results demonstrate that the NTS may be involved in the control of nociceptive transmission at the spinal cord level.