Human cancers express mutator phenotypes: origin, consequences and targeting.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21593786.
- Also identified by DOI 10.1038/nrc3063 and PMC identifier 4007007.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.
Medical subject headings
- DNA Repair
- Mutation
- Neoplasms