Steering carbon nanotubes to scavenger receptor recognition by nanotube surface chemistry modification partially alleviates NFκB activation and reduces its immunotoxicity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21595480.
- Also identified by DOI 10.1021/nn200283g and PMC identifier 3138538.
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Abstract
Carbon nanotubes (CNTs) cause perturbations in immune systems and limit the application of CNTs in biomedicine. Here we demonstrate that a surface chemistry modification on multiwalled CNTs (MWCNTs) reduces their immune perturbations in mice and in macrophages. The modified MWCNTs change their preferred binding pattern from mannose receptor to scavenger receptor. This switch significantly alleviates NFκB activation and reduces immunotoxicity of MWCNTs.
Medical subject headings
- Nanotubes, Carbon