Bioinformatics challenges for personalized medicine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21596790.
- Also identified by DOI 10.1093/bioinformatics/btr295 and PMC identifier 3117361.
- Licence recorded as CC BY-NC.
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Abstract
Widespread availability of low-cost, full genome sequencing will introduce new challenges for bioinformatics. This review outlines recent developments in sequencing technologies and genome analysis methods for application in personalized medicine. New methods are needed in four areas to realize the potential of personalized medicine: (i) processing large-scale robust genomic data; (ii) interpreting the functional effect and the impact of genomic variation; (iii) integrating systems data to relate complex genetic interactions with phenotypes; and (iv) translating these discoveries into medical practice. russ.altman@stanford.edu
Medical subject headings
- Computational Biology
- Human Genome Project
- Precision Medicine