Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki disease.
Level V
Where this comes from
- Record sourced from PubMed, PMID 21601260.
- Also identified by DOI 10.1016/j.jaci.2011.04.027 and PMC identifier 3444515.
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Abstract
In Kawasaki Disease patients, the authors show associations between high-dose intravenous immunoglobulin (IVIG) response and a polymorphism in the FCγRIIB. This provides basis for defining the IVIG regulatory mechanisms and pharmacogenomic approach to IVIG therapy.
Medical subject headings
- Genetic Variation
- Immunoglobulins, Intravenous
- Mucocutaneous Lymph Node Syndrome
- Receptors, IgG