Enhancement of human herpesvirus 6 replication in adult human lymphocytes by monoclonal antibody to CD3.
basic_science · Level V
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Abstract
The effect of monoclonal antibody to CD3 on human herpesvirus 6 (HHV-6) replication was assessed in adult peripheral blood mononuclear cells (PBMC) and in cord blood mononuclear cells (CBMC) by anticomplement immunofluorescence and Southern blot hybridization. Infection of CBMC by HHV-6 was productive; however, little or no infection was observed with PBMC from adults exposed to the virus even if stimulated by phytohemagglutinin. Monoclonal antibody to CD3 strongly enhanced HHV-6 replicative cycles in PBMC from adults.
Medical subject headings
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- Herpesvirus 6, Human
- Lymphocytes
- Receptors, Antigen, T-Cell