PK-M2 Makes Cells Sweeter on HIF1.
basic_science · Level V
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- Record sourced from PubMed, PMID 21620132.
- Also identified by DOI 10.1016/j.cell.2011.05.009.
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Abstract
The transcription factor hypoxia-inducible factor 1 (HIF1) facilitates the induction of enzymes necessary for anaerobic glycolysis. Luo et al. (2011) now identify pyruvate kinase (PK)-M2 as an intriguing new interacting partner for HIF1, revealing a potential mechanism for the Warburg effect, an elevation in aerobic glycolytic metabolism frequently observed in cancer.