Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 21620500.
- Also identified by DOI 10.1016/j.radonc.2011.05.007.
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Abstract
Many genes have been associated with radiotherapy toxicity, but most have only been found in a single study. Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy.
Medical subject headings
- Breast Neoplasms
- DNA Ligases
- DNA Repair
- Polymorphism, Single Nucleotide
- Radiation Injuries
- Radiotherapy
- Skin