The cell biology of the unfolded protein response.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21620842.
- Also identified by DOI 10.1053/j.gastro.2011.05.018 and PMC identifier 3129462.
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Abstract
The unfolded protein response (UPR) is an ensemble of signal transduction pathways that respond to perturbations in the oxidative, pro-folding environment of the endoplasmic reticulum. During the past decade, ongoing research implicated these pathways in maintaining homeostasis of cells and organisms exposed to various stresses. Herein, we highlight recent findings regarding the functional role of the UPR in both normal and pathophysiologic processes.
Medical subject headings
- Endoplasmic Reticulum
- Protein Folding
- Signal Transduction
- Unfolded Protein Response