Notch and basal cells take center stage during airway epithelial regeneration.
editorial · Level V
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- Record sourced from PubMed, PMID 21624798.
- Also identified by DOI 10.1016/j.stem.2011.05.008.
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Abstract
Airway epithelium is maintained by basal cells, but the mechanisms responsible for repair are poorly characterized. In this issue of Cell Stem Cell, Rock et al. (2011) show that Notch signals regulate differentiation, but not self-renewal of basal cells after injury, and that this role appears conserved in mouse and human lung.