Taking HSCs down a Notch in leukemia.
editorial · Level V
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- Record sourced from PubMed, PMID 21624800.
- Also identified by DOI 10.1016/j.stem.2011.04.010.
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Abstract
The Notch signaling pathway is activated in the majority of T cell acute lymphoblastic leukemias (T-ALL). Adding to the complexity of Notch signaling in hematopoiesis, recently in Nature, Klinakis et al. (2011) demonstrate a tumor-suppressor function for the Notch pathway in myeloid malignancy.