Biocompatible multi-address 3D cell assembly in microfluidic devices using spatially programmable gel formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21629950.
- Also identified by DOI 10.1039/c1lc20306a.
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Abstract
Programmable 3D cell assembly under physiological pH conditions is achieved using electrodeposited stimuli-responsive alginate gels in a microfluidic device, with parallel sidewall electrodes enabling direct observation of the cell assembly. Electrically triggered assembly and subsequent viability of mammalian cells is demonstrated, along with spatially programmable, multi-address assembly of different strains of E. coli cells. Our approach enables in vitro study of dynamic cellular and inter-cellular processes, from cell growth and stimulus/response to inter-colony and inter-species signaling.
Medical subject headings
- Gels