N-methyl-D-aspartate antagonist reduces stroke size and regional glucose metabolism.
basic_science · Level V
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Abstract
Pharmacological inhibition of cell excitation during focal ischemia was studied in the rat middle cerebral artery occlusion model. The potent and selective N-methyl-D-aspartate antagonist CGS 19755, administered 5 minutes prior to or 5 minutes following permanent middle cerebral artery occlusion, caused a substantial decrease in infarct size, which was associated with reduction of postischemic cerebral glucose hypermetabolism. These data support a role for excitation-induced hypermetabolism in the pathogenesis of infarction following focal cerebrovascular occlusion.
Medical subject headings
- Deoxy Sugars
- Deoxyglucose
- Ischemic Attack, Transient
- Pipecolic Acids
- Piperidines
- Receptors, Neurotransmitter