Is cytomegalovirus a therapeutic target in glioblastoma?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21632859.
- Also identified by DOI 10.1158/1078-0432.CCR-11-0992.
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Abstract
Several investigators have now demonstrated the expression of genes unique to cytomegalovirus (CMV) in malignant gliomas. Many of these genes promote oncogenesis, alter tumor microenvironment, and serve as immunologic targets. Is the level of CMV infection within tumor cells sufficient to drive important oncogenic or immunosuppressive processes? Can CMV serve as a target for therapeutic intervention?
Medical subject headings
- Brain Neoplasms
- Cytomegalovirus
- Glioblastoma
- Monocytes