Inflammatory links between obesity and metabolic disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21633179.
- Also identified by DOI 10.1172/JCI57132 and PMC identifier 3104776.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity. This has led to a convergence of the fields of immunology and nutrient physiology and the understanding that they are inextricably linked. The reframing of obesity as an inflammatory condition has had a wide impact on our conceptualization of obesity-associated diseases. In this Review, we highlight the cellular and molecular mechanisms at play in the generation of obesity-induced inflammation. We also emphasize how defining the immune regulation in metabolic tissues has broadened the understanding of the diversity of inflammatory responses.
Medical subject headings
- Inflammation
- Metabolic Diseases
- Obesity