A novel mediator between activator proteins and the RNA polymerase II transcription apparatus.
basic_science · Level V
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Abstract
One gene activator protein may interfere with the effects of another in eukaryotic cells. We report here that a hybrid yeast-herpes gene activator protein inhibits transcriptional activation by a thymidine-rich DNA element in yeast. This example of activator interference can be faithfully reproduced in vitro. Interference is reversed by a partially purified yeast component, but not by RNA polymerase II or various polymerase II transcription factors. We conclude that the partially purified yeast component is a novel factor, and we suggest this factor mediates the transcriptional activation process.
Medical subject headings
- Fungal Proteins
- Phosphoproteins
- RNA Polymerase II
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Trans-Activators
- Transcription Factors
- Transcription, Genetic