Pharmacology of spinal opioids.
review · Level V
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- Record sourced from PubMed, PMID 2164071.
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Abstract
This review presents the pharmacology of spinal opioid receptor systems which are primarily involved in pain processing. The major areas upon which we will focus are: the structure and cellular functioning of the opioid receptor systems; the physiologic effects induced by spinally administered opioids, particularly in pain modulation; and pharmacokinetic and dynamic considerations, with special attention to the problem of opioid tolerance development.
Medical subject headings
- Analgesia, Epidural
- Narcotics
- Pain