PTPMT1: connecting cardiolipin biosynthesis to mitochondrial function.
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- Record sourced from PubMed, PMID 21641541.
- Also identified by DOI 10.1016/j.cmet.2011.05.005.
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Abstract
Cardiolipin, a phospholipid component of the inner mitochondrial membrane, is required for mitochondrial metabolism. In this issue, Zhang et al. (2011) highlight a critical role for PTPMT1, a mitochondrial phosphatase, in cardiolipin biogenesis and possibly in cardiolipin deficiency diseases. Their findings also unveil a yet uncharacterized pathway affecting cell growth.