A radical role for TOR in longevity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21641542.
- Also identified by DOI 10.1016/j.cmet.2011.05.006 and PMC identifier 3121179.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
TOR (target of rapamycin) signaling regulates life span in many organisms, but the mechanism behind the effect is unknown. In this issue of Cell Metabolism, Pan and colleagues (2011) find that reduced TORC1 activity promotes yeast life span via a mechanism that, paradoxically, relies upon the production of normally deleterious reactive oxygen species.