genBlastG: using BLAST searches to build homologous gene models.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21653517.
- Also identified by DOI 10.1093/bioinformatics/btr342.
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Abstract
BLAST users frequently expect to obtain homologous genes with certain similarity to their query genes. But what they get from BLAST searches are often collections of local alignments called high-scoring segment pairs (HSPs). On the other hand, most homology-based gene finders have been built using computation-intensive algorithms, without taking full advantage of BLAST searches that have been perfected over the last decades. Here we report an efficient algorithm, genBlastG that directly uses the HSPs reported by BLAST to define high-quality gene models. http://genome.sfu.ca/genblast/download.html
Medical subject headings
- Algorithms
- Computational Biology
- Models, Genetic