Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21657258.
- Also identified by DOI 10.1021/nl2011214 and PMC identifier 3135732.
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Abstract
Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.
Medical subject headings
- Cell Transformation, Neoplastic
- Epithelial Cells
- Lung
- Nanotubes, Carbon