A novel function of the transforming domain of E1a: repression of AP-1 activity.
basic_science · Level V
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Abstract
Adenovirus E1a represses transcription of the collagenase gene via the phorbol ester-responsive element (collTRE). The mechanism involves inhibition of the trans-activating function of the transcription factor AP-1 without reduction of its synthesis and without any apparent change in DNA binding or composition. The ability of E1a to downmodulate AP-1 is a unique property among dominant oncogenes. This repression depends on conserved region 1, one of the transforming domains of E1a, indicating that it is an integral feature of adenovirus transformation.
Medical subject headings
- DNA-Binding Proteins
- Microbial Collagenase
- Oncogene Proteins, Viral
- Transcription Factors
- Transcription, Genetic