The LabelHash server and tools for substructure-based functional annotation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21659320.
- Also identified by DOI 10.1093/bioinformatics/btr343.
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Abstract
The LabelHash server and tools are designed for large-scale substructure comparison. The main use is to predict the function of unknown proteins. Given a set of (putative) functional residues, LabelHash finds all occurrences of matching substructures in the entire Protein Data Bank, along with a statistical significance estimate and known functional annotations for each match. The results can be downloaded for further analysis in any molecular viewer. For Chimera, there is a plugin to facilitate this process. The web site is free and open to all users with no login requirements at http://labelhash.kavrakilab.org
Medical subject headings
- Databases, Protein
- Internet
- Molecular Sequence Annotation
- Proteins