Treating the periphery to ameliorate neurodegenerative diseases.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21663784.
- Also identified by DOI 10.1016/j.cell.2011.05.031.
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Abstract
Abnormalities in the kynurenine pathway are associated with neurodegenerative disorders. Zwilling et al. (2011) show that inhibition of kynurenine 3-monooxygenase in the body's periphery leads to an increase in kyneuric acid, a neuroprotective compound, in the brain. This intervention ameliorates neurodegeneration in mouse models of Alzheimer's disease and Huntington's disease.