Cell fate plug and play: direct reprogramming and induced pluripotency.
review · Level V
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- Record sourced from PubMed, PMID 21663788.
- Also identified by DOI 10.1016/j.cell.2011.05.036.
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Abstract
Building on the discovery that MyoD expression reprograms fibroblasts into muscle, three papers (Vierbuchen et al., 2010; Ieda et al., 2010; Szabo et al., 2010) recently reported the reprogramming of fibroblasts into neurons, cardiomyocytes, and blood cell progenitors without first passing the cells through a pluripotent state. Here we discuss the advantages and challenges of harnessing this direct reprogramming method for regenerative medicine.
Medical subject headings
- Cellular Reprogramming
- Induced Pluripotent Stem Cells
- Regenerative Medicine