Three-dimensional high-resolution imaging of gold nanorods uptake in sentinel lymph nodes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21667930.
- Also identified by DOI 10.1021/nl2014394 and PMC identifier 3135710.
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Abstract
In this paper, we demonstrate an application of a noninvasive imaging modality, photothermal optical coherence tomography (PT-OCT), for imaging gold nanorods (GNRs) uptake in sentinel lymph node (SLN) of mice in situ. This application enables us to obtain higher quality images of SLN structures due to the photothermal contrast properties of the GNRs. It is also demonstrated that GNRs accumulate differently within several SLN structures, and this uptake is time dependent. Finally, we determine the average concentration of GNRs within the whole SLN which is used to demonstrate uptake kinetics of the nanoparticles.
Medical subject headings
- Gold
- Lymph Nodes
- Metal Nanoparticles