Histological changes in glioblastoma after intratumoral injection of autologous lymphocytes and human lymphoblastoid interferon.
case_series · Level IV
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Abstract
Seven glioblastomas were studied between 1 and 6 months after intratumoral injection of autologous lymphocytes and human lymphoblastoid interferon. Morphological study showed a great number of lymphocytes within the tumor tissue, and interactions between lymphocytes and glioblastoma cells, suggesting a killing phenomenon. These data support the potential usefulness of adoptive immunotherapy in patients with glioblastoma by means of intratumoral administration of activated lymphoid cells.
Medical subject headings
- Brain Neoplasms
- Glioblastoma
- Immunotherapy
- Interferon Type I
- Lymphocytes