Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.
basic_science · Level V
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- Record sourced from PubMed, PMID 21670305.
- Also identified by DOI 10.1073/pnas.1104830108 and PMC identifier 3127873.
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Abstract
Signaling pathways essential for axon regeneration, but not for neuron development or function, are particularly well suited targets for therapeutic intervention. We find that the parallel PMK-3(p38) and KGB-1(JNK) MAPK pathways must be coordinately activated to promote axon regeneration. Axon regeneration fails if the activity of either pathway is absent. These two MAPKs are coregulated by the E3 ubiquitin ligase RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates both PMK-3(p38) and KGB-1(JNK).
Medical subject headings
- Axons
- MAP Kinase Kinase 4
- Nerve Regeneration
- p38 Mitogen-Activated Protein Kinases