Inherited IgA glycosylation pattern in IgA nephropathy and HSP nephritis: where do we go next?
editorial · Level V
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- Record sourced from PubMed, PMID 21673733.
- Also identified by DOI 10.1038/ki.2011.83.
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Abstract
New data from Kiryluk et al. show the importance of genetic factors in determining the profile of serum IgA1 O-glycoforms in IgA nephropathy and Henoch-Schönlein purpura nephritis. Elevated serum levels of poorly galactosylated IgA1 O-glycoforms do not, however, appear sufficient in themselves to cause nephritis in these two diseases, and a 'second hit' is necessary before changes in IgA1 glycosylation translate into clinical disease. The challenge now is to determine what these genetic factors are.
Medical subject headings
- Glomerulonephritis, IGA
- IgA Vasculitis
- Immunoglobulin A
- Nephritis, Hereditary