Protein synthesis: Stop the nonsense.
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- Record sourced from PubMed, PMID 21677740.
- Also identified by DOI 10.1038/474289a and PMC identifier PMC2801282.
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Abstract
The amino acid sequence of proteins is specified by trinucleotides (codons), and their ends by one of three stop codons. A new study reveals how a subtle biochemical alteration can reprogram stop codons into amino acid-encoding codons at the messenger RNA (mRNA) level, without altering the DNA from which the mRNA is transcribed.