Opportunistic infection-associated immune reconstitution syndrome in transplant recipients.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21690625.
- Also identified by DOI 10.1093/cid/cir276.
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Abstract
Reversal of pathogen-induced immunosuppression upon employment of effective antimicrobial therapy and withdrawal of iatrogenic immunosuppression has the potential to shift the host immune repertoire towards pathologic inflammatory responses conducive to immune reconstitution syndrome (IRS). Posttransplant IRS has been observed with fungi, M. tuberculosis, cytomegalovirus, and polyoma virus nephropathy. This review discusses the existing state of knowledge regarding IRS and the immune mechanisms that underlie its pathogenesis, with significant implications for developing reliable diagnostic biomarkers and optimal management strategies for post-transplant opportunistic infection-associated IRS.
Medical subject headings
- Immune Reconstitution Inflammatory Syndrome
- Immunosuppressive Agents
- Opportunistic Infections
- Transplantation