Novel inflammatory mechanisms of accelerated atherosclerosis in kidney disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21697810.
- Also identified by DOI 10.1038/ki.2011.178.
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Abstract
A substantial body of evidence has accumulated linking an increased incidence of cardiovascular disease in patients with acute kidney injury (AKI), chronic kidney disease (CKD), and end-stage renal disease (ESRD). A multitude of novel risk factors related to decreased kidney function might interact with the renal and systemic immune systems involved in renal injury and repair to participate in accelerated atherogenesis (Immune inflammation-Renal injury-Atherosclerosis--the IRA Paradigm). In this review, we will discuss several of these novel risk factors and present the potential for the role of the immune-inflammatory system in accelerated atherosclerosis of kidney disease.
Medical subject headings
- Atherosclerosis
- Inflammation
- Kidney Diseases