Chromatin-based mechanisms of renal epithelial differentiation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21700830.
- Also identified by DOI 10.1681/ASN.2010101018 and PMC identifier 3137568.
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Abstract
Successful regenerative renal medicine depends on understanding the molecular mechanisms by which diverse phenotypes of epithelial cells differentiate from metanephric mesenchyme to populate nephrons. Whereas many genes are maintained in a poised state within the population of pluripotent progenitors, specialized epithelial functions reflect the selective expression of a subset of genes and the repression of all others. Here we highlight some common mechanisms of cell differentiation and epigenetic regulation to discuss their implications for renal epithelial development, repair, and disease.
Medical subject headings
- Cell Differentiation
- Chromatin
- Epigenesis, Genetic
- Epithelial Cells
- Kidney